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Delineating the Anti-Cytotoxic and Anti-Genotoxic Potentials of Catechin Hydrate Against Cadmium Toxicity in Human Peripheral Blood Lymphocytes

Delineating the Anti-Cytotoxic and Anti-Genotoxic Potentials of Catechin Hydrate Against Cadmium Toxicity in Human Peripheral Blood Lymphocytes

Ali A Alshatwi, Tarique N Hasan, Ali M Alqahtani, Naveed A Syed, Gowhar Shafi, Abdullah H Al-Assaf, Abdulrahmann S Al-Khalifa

Environ Toxicol Pharmacol. 2014 Sep;38(2):653-62.

PMID: 25218093

Abstract:

Catechins (flavan-3-ol) are a type of natural phenol and well-studied antioxidants. Catechin hydrate, also known as taxifolin; is non-mutagenic, low in toxicity compared to other immunomodulator antioxidants. We aimed to determine the potential of catechin hydrate to prevent the cyto-genotoxic effects of cadmium in lymphocytes; demonstrate the immuno-protective activity of catechin hydrate. Our previous study indicated that cadmium is apoptogenic. Lymphocytes were treated with catechin hydrate or cadmium and catechine hydrate combinations (range 0.1-100μM) to determine their effects on cell viability. Lymphocytes treated with 100μM catechin hydrate and 100μM cadmium showed cell viability 70.65±6.92% and 5.69±2.27%, respectively. In our previous study cadmium (10 and 20μM) induced apoptosis in 31.8% and 44.4% of lymphocytes, respectively. However, the percentage of apoptotic cells after treatment with the combination of cadmium and catechin hydrate was not significantly different from that of catechin hydrate (P>0.05). Only 7.3% and 10.5% of the lymphocytes were apoptotic after treatment with 10μM cadmium+10μM catechin hydrate and 20μM cadmium+20μM catechin hydrate, respectively. The anti-geno-cytotoxic and immuno-protective potential of catechin hydrate was also demonstrated by the non-significant expression of apoptosis-related genes after treatment with catechin hydrate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP24198978	(±)-Taxifolin hydrate		24198-97-8 (anhydrous)	Price

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