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Demeclocycline. Treatment for Syndrome of Inappropriate Antidiuretic Hormone Secretion

Demeclocycline. Treatment for Syndrome of Inappropriate Antidiuretic Hormone Secretion

A De Troyer

JAMA. 1977 Jun 20;237(25):2723-6.

PMID: 194065

Abstract:

The efficacy of demeclocycline hydrochloride in suppressing the tubular action of tumoral antidiuretic products was tested in seven patients with the syndrome of inappropriate antidiuretic hormone secretion. In all patients, demeclocycline hydrochloride (1,200 mg/day) induced production of hypotonic urine and corrected hyponatremia despite large fluid intakes. Comparison of the response to a standard water load before and during treatment showed a notable improvement in the response to water ingestion. Even though demeclocycline moderately impairs renal function, it appears to be the treatment of choice in the chronic form of the syndrome.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP64733-B	Demeclocycline hydrochloride		64-73-3	Price

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