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Depolymerization of Chondroitin 6-sulfate and Dermatan Sulfate With Diazomethane in the Presence of a Small Proportion of Water

Depolymerization of Chondroitin 6-sulfate and Dermatan Sulfate With Diazomethane in the Presence of a Small Proportion of Water

Y Inoue, K Nagasawa

Carbohydr Res. 1986 Feb 1;146(2):271-8.

PMID: 3082515

Abstract:

Chondroitin 6-sulfate (sodium salt), dermatan sulfate (sodium salt), and their methyl esters were depolymerized into mixtures of methylated, even-numbered oligosaccharides having a 4,5-unsaturated uronic acid, nonreducing end-group, respectively, with excess diazomethane in the presence of a small proportion of water. The methyl ester of chondroitin 6-sulfate was more effectively cleaved than the sodium salt, whereas the methyl ester of dermatan sulfate was depolymerized at a rate slightly higher than the sodium salt. About half of the acetamido group in the depolymerized product of the methyl ester of these polysaccharides was N-methylated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP54328335-C	Chondroitin sulfate B sodium salt		54328-33-5	Price

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