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Depsidomycins B and C: New Cyclic Peptides From a Ginseng Farm Soil-Derived Actinomycete

Depsidomycins B and C: New Cyclic Peptides From a Ginseng Farm Soil-Derived Actinomycete

Yun Kwon, Woong Sub Byun, Byung-Yong Kim, Myoung Chong Song, Munhyung Bae, Yeo Joon Yoon, Jongheon Shin, Sang Kook Lee, Dong-Chan Oh

Molecules. 2018 May 25;23(6):1266.

PMID: 29799492

Abstract:

LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess d-leucine, d-threonine, d-valine, and S-piperazic acid based on the advanced Marfey's method and a GITC (2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14152977	2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate		14152-97-7	Price

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