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Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an Imidazoline Binding Sites Ligand, With (+)-(R)-alpha-methylbenzyl Isocyanate for Drug Monitoring Purposes

Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an Imidazoline Binding Sites Ligand, With (+)-(R)-alpha-methylbenzyl Isocyanate for Drug Monitoring Purposes

Myriam Matoga, Isabelle Forfar, Corinne Chaimbault, Jean Guillon, Fabienne Péhourcq, Jean-Jacques Bosc, Marie-Claire Rettori, Christian Jarry

J Enzyme Inhib Med Chem. 2002 Dec;17(6):375-9.

PMID: 12683672

Abstract:

The derivatization of racemic 5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, developed as an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate was performed in chloroform. The reaction led to two pairs of diastereomers, which were separated by RP-HPLC. A kinetic study of the derivatization reaction was achieved in order to establish conditions suitable for experimental drug monitoring.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33375063	(R)-(+)-α-Methylbenzyl isocyanate		33375-06-3	Price

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