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Desensitizing Toothpaste Versus Placebo for Dentin Hypersensitivity: A Systematic Review and Meta-Analysis

Desensitizing Toothpaste Versus Placebo for Dentin Hypersensitivity: A Systematic Review and Meta-Analysis

Ji-Hyun Bae, Young-Kyun Kim, Seung-Kwon Myung

J Clin Periodontol. 2015 Feb;42(2):131-41.

PMID: 25483802

Abstract:

Aim:
The aim is to assess the effect of desensitizing toothpaste on dentin hypersensitivity.
Methods:
We searched PubMed, CENTRAL, and Embase on December 20, 2013.
Results:
Out of the 626 articles searched, a total of 31 randomized controlled clinical trials were included. The Standardized mean differences (SMD) for potassium-containing toothpaste (n = 8) was -1.28 (95% Confidence interval (CI) -2.05 to -0.51; I(2) = 93%); Stannous fluoride- (n = 6) was -1.37 (95% CI, -2.30 to -0.44; I(2) = 95%); Potassium and stannous fluoride- (n = 3) was -2.50 (95% CI, -4.10 to -0.91; I(2) = 95%); Calcium sodium phosphosilicate- (n = 4) was -2.36 (95% CI, -3.72 to -1.00; I(2) = 92%); Arginine- (n = 8) was -3.25 (95% CI, -3.87 to -2.63; I(2) = 86%). The desensitizing effect was favoured in the intervention group treated with potassium-, stannous fluoride-, potassium and stannous fluoride-, calcium sodium phosphosilicate-, and arginine-containing toothpaste compared to placebo. Whereas, strontium-containing toothpaste (SMD, 0.05; 95% CI, -0.34 to 0.44; I(2) = 64%) was found to have no statistically significant desensitizing effect in the meta-analysis of four studies.
Conclusions:
The study reports that there is sufficient evidence to support the use of potassium-, stannous fluoride-, potassium and stannous fluoride-, calcium sodium phosphosilicate-, and arginine-containing desensitizing toothpastes for dentin hypersensitivity, but not the use of strontium-containing desensitizing toothpaste.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1374247423	Potassium 2,6-dimethoxypyridine-3-trifluoroborate		1374247-42-3	Price

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