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Design and Evaluation of Ocusert for Controlled Delivery of Flurbiprofen Sodium

Design and Evaluation of Ocusert for Controlled Delivery of Flurbiprofen Sodium

Hitesh Kulhari, Deep Pooja, Harihar Narayan, Lokesh Meena, S K Prajapati

Curr Eye Res. 2011 May;36(5):436-41.

PMID: 21501077

Abstract:

Purpose:
The basic objective of this study is to develop the Flurbiprofen sodium soluble ocusert to increase patient compliance by improving local delivery of the drug.
Materials and methods:
Three different polymers were used in combination to prepare the rate controlling membrane. The drug reservoir was prepared by using hydroxy propyl methyl cellulose. Ocuserts were evaluated for their physicochemical parameters. The optimized formulations were further evaluated for accelerated stability studies, eye irritancy tests, and for in vivo drug release studies.
Results:
Ocuserts were found stable at room temperature and showed a strong positive correlation between in vitro and in vivo drug release.
Conclusion:
An appropriate combination of hydrophilic and hydrophobic polymers provides better control of drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP1584155623	Flurbiprofen sodium		1584155-62-3 (anhydrous)	Price

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