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Design and Synthesis of Conformationally Constrained Analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-specific Phosphodiesterase

Design and Synthesis of Conformationally Constrained Analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-specific Phosphodiesterase

M F Brackeen, D J Cowan, J A Stafford, F J Schoenen, J M Veal, P L Domanico, D Rose, A B Strickland, M Verghese, P L Feldman

J Med Chem. 1995 Nov 24;38(24):4848-54.

PMID: 7490734

Abstract:

The synthesis and biological evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described. The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazolidinones, imidazolidinones, and pyrrolizidinones that mimic Ro 20-1724 but differ in the orientation of the carbonyl group. The endo isomer of each of these heterocycles was more potent than the exo isomer in an enzyme inhibition assay and a cellular assay, which measured TNF alpha secretion from activated human peripheral blood monocytes (HPBM). Imidazolidinone 4a inhibited human PDE IV with a Ki of 27 nM and TNF alpha secretion from HPBM with an IC50 of 290 nM. By comparison, Ro 20-1724 is significantly less active in these assays with activities of 1930 and 1800nM, respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP29925175-A	4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one		29925-17-5	Price

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