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Design and Synthesis of imidazo[1,2-α][1,8]naphthyridine Derivatives as anti-HCV Agents via Direct C-H Arylation

Design and Synthesis of imidazo[1,2-α][1,8]naphthyridine Derivatives as anti-HCV Agents via Direct C-H Arylation

Shengdian Huang, Jie Qing, Shuo Wang, Huan Wang, Linqi Zhang, Yefeng Tang

Org Biomol Chem. 2014 Apr 21;12(15):2344-8.

PMID: 24595428

Abstract:

RO8191 represents a newly identified small-molecule IFN-α-substitute, which displays potent anti-HCV activity. In this communication, we reported the design and synthesis of two series of imidazo[1,2-α][1,8]naphthyridine derivatives, as RO8191 analogues, via a direct C-H arylation approach. Notably, by adjusting the reaction conditions, we could achieve the two series of analogues via regioselective single- and double-arylations, respectively. The anti-HCV activities of the synthesized compounds were evaluated within the HCV cell culture system, and the preliminary results showed that some of them displayed promising anti-HCV activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP691868889	RO8191		691868-88-9	Price

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