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Design, Synthesis and Biological Evaluation of Novel Hamamelitannin Analogues as Potentiators for Vancomycin in the Treatment of Biofilm Related Staphylococcus Aureus Infections

Design, Synthesis and Biological Evaluation of Novel Hamamelitannin Analogues as Potentiators for Vancomycin in the Treatment of Biofilm Related Staphylococcus Aureus Infections

Arno Vermote, Gilles Brackman, Martijn D P Risseeuw, Tom Coenye, Serge Van Calenbergh

Bioorg Med Chem. 2016 Oct 1;24(19):4563-4575.

PMID: 27507109

Abstract:

Staphylococcus aureus is a frequent cause of biofilm-related infections. Bacterial cells within a biofilm are protected from attack by the immune system and conventional antibiotics often fail to penetrate the biofilm matrix. The discovery of hamamelitannin as a potentiator for antibiotics, recently led to the design of a more drug-like lead. In the present study, we want to gain further insight into the structure-activity relationship (S.A.R.) of the 5-position of the molecule, by preparing a library of 21 hamamelitannin analogues.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP469329	Hamamelitannin		469-32-9	Price

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