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Design, Synthesis, and Biological Evaluation of Novel Nitric Oxide Releasing Dehydroandrographolide Derivatives

Design, Synthesis, and Biological Evaluation of Novel Nitric Oxide Releasing Dehydroandrographolide Derivatives

Lin Yan, Yu-Xuan Dai, Guo-Long Gu, Miao-Bo Pan, Shuai-Cong Wu, Yu Cao, Wen-Long Huang

Chin J Nat Med. 2018 Oct;16(10):782-790.

PMID: 30322612

Abstract:

A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC50 1.55 μmol·L-1) and MCF-7 (IC50 2.91 μmol·L-1) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger. In conclusion, I-5 is a novel hybrid with potent antitumor activity and may become a promising candidate for future intensive study.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP134418283	Dehydroandrographolide		134418-28-3	Price

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