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Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO₂) as Antimycobacterial Agents

Satish R Malwal, Dharmarajan Sriram, Perumal Yogeeswari, V Badireenath Konkimalla, Harinath Chakrapani

J Med Chem. 2012 Jan 12;55(1):553-7.

PMID: 22128803

Abstract:

Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO(2) release profiles with half-lives of SO(2) release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP57620221 N-Benzyl-2,4-dinitrobenzenesulfonamide N-Benzyl-2,4-dinitrobenzenesulfonamide 57620-22-1 Price
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