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Design, Synthesis and Pharmacological Analysis of 5-[4'-(substituted-methyl)[1,1'-biphenyl]-2-yl]-1H-tetrazoles

Design, Synthesis and Pharmacological Analysis of 5-[4'-(substituted-methyl)[1,1'-biphenyl]-2-yl]-1H-tetrazoles

Atulkumar Kamble, Ravindra Kamble, Suneel Dodamani, Sunil Jalalpure, Vijaykumar Rasal, Mahadev Kumbar, Shrinivas Joshi, Sheshagiri Dixit

Arch Pharm Res. 2017 Apr;40(4):444-457.

PMID: 28083853

Abstract:

In the present paper 5-[4'-({4-[(4-aryloxy)methyl]-1H-1,2,3-triazol-1-yl}methyl)[1,1'-biphenyl]-2-yl]-1H-tetrazoles (5a-g) and [2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-substituted-1-carbodithioates (11h-q) have been designed and synthesized. These compounds were subjected to docking (against AT1 receptor protein enzyme in complex with Lisinopril), in vitro angiotensin converting enzyme inhibition, anti-proliferative, anti-inflammatory screening (through egg albumin denaturation inhibition and red blood cell membrane stabilization assay) and finally anti-fungal activity analyses. Some of the compounds have shown significant pharmacological properties.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16400503	3,3′,5,5′-Tetrabromo-1,1′-biphenyl		16400-50-3	Price

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