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Detection of Macrophage Inflammatory Protein (MIP)-1alpha and MIP-1beta During Experimental Endotoxemia and Human Sepsis

Detection of Macrophage Inflammatory Protein (MIP)-1alpha and MIP-1beta During Experimental Endotoxemia and Human Sepsis

N P O'Grady, M Tropea, H L Preas 2nd, D Reda, R W Vandivier, S M Banks, A F Suffredini

J Infect Dis. 1999 Jan;179(1):136-41.

PMID: 9841832

Abstract:

Macrophage inflammatory protein (MIP)-1alpha and MIP-1beta regulate leukocyte activation and trafficking. To assess the role of MIP-1alpha and MIP-1beta in human inflammation, healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen, a cyclooxygenase inhibitor, or dimeric p75 tumor necrosis factor (TNF)-alpha receptor, a TNF antagonist; septic patients were also studied. Following endotoxin, blood levels of both MIP-1 molecules rose acutely and fell to baseline by 6 h (P=. 001). While MIP-1 mediates fever in animals independent of cyclooxygenase blockade, in subjects given endotoxin and ibuprofen, MIP-1 levels increased and fever was suppressed. MIP-1 levels were not diminished by inhibiting circulating TNF-alpha in humans. In septic patients, elevated levels of MIP-1alpha and MIP-1beta were detected within 24 h of sepsis and fell in parallel with TNF-alpha and interleukin-6 (P<.01). MIP-1alpha and MIP-1beta increase during acute inflammation but are not associated with fever in endotoxemic humans during cyclooxygenase blockade.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248673	MIP-1alpha human			Price

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