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Determination of Alentamol Hydrobromide, a Novel Antipsychotic Agent, in Human Blood Plasma and Urine by High-Performance Liquid Chromatography With Fluorescence Detection and Solid-Phase Extraction

Determination of Alentamol Hydrobromide, a Novel Antipsychotic Agent, in Human Blood Plasma and Urine by High-Performance Liquid Chromatography With Fluorescence Detection and Solid-Phase Extraction

F J Schwende, U M Rykert

J Chromatogr. 1991 Apr 19;565(1-2):488-96.

PMID: 1874898

Abstract:

Alentamol hydrobromide, (+)-2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol monohydrobromide, is a selective dopamine agonist currently being investigated for the treatment of schizophrenia. This paper describes a reversed-phase high-performance liquid chromatographic-based method for the quantification of alentamol in blood plasma and urine. The method utilizes solid-phase extraction with carboxylic acid-derivatized silica columns. A limit of quantitation of 0.1 ng/ml in plasma was achieved by virtue of selective extraction and fluorescence detection. Example chromatograms of plasma and urine specimens from clinical trials demonstrate the utility of the method.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4242436	BSc3094 monohydrobromide			Price

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