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Determination of Ampicillin Sodium Using the Cupric Oxide nanoparticles-luminol-H2 O2 Chemiluminescence Reaction

Determination of Ampicillin Sodium Using the Cupric Oxide nanoparticles-luminol-H2 O2 Chemiluminescence Reaction

Mortaza Iranifam, Merhnaz Khabbaz Kharameh

Luminescence. 2014 Sep;29(6):679-83.

PMID: 24254330

Abstract:

A simple and sensitive chemiluminescence (CL) method has been developed for the determination of ampicillin sodium at submicromolar levels. The method is based on the inhibitory effect of ampicillin sodium on the cupric oxide nanoparticles (CuO NPs)-luminol-H2 O2 CL reaction. Experimental parameters affecting CL inhibition including concentrations of CuO NPs, luminol, H2 O2 and NaOH were optimized. Under optimum conditions, the calibration plot was linear in the analyte concentration range 4.0 × 10(-7) -4.0 × 10(-6) mol/L. The limit of detection was 2.6 × 10(-7) mol/L and the relative standard deviation (RSD) for six replicate determinations of 1 × 10(-6) mol/L ampicillin sodium was 4.71%. Also, X-ray diffraction (XRD) and transmission electron microscopy (TEM) analysis were employed to characterize the CuO NPs. The utility of the proposed method was demonstrated by determining ampicillin sodium in pharmaceutical preparation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP69523-B	Ampicillin Sodium		69-52-3	Price

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