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[Determination of Flavonoids Constituents in Epimedium Total Flavone Capsule and Research on Its Anti-Osteoporosis Activity]

[Determination of Flavonoids Constituents in Epimedium Total Flavone Capsule and Research on Its Anti-Osteoporosis Activity]

Zhong-Kun Xu, Hong-Mei Yin, Fang Li, Jian-Ping Qin, Shao-Li Gu, Yun Wu, Zhen-Zhong Wang, Wei Xiao

Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(15):3140-3144.

PMID: 30200709

Abstract:

To develop a rapid resolution liquid chromatography (RRLC) method for the simultaneous determination of epimedoside A, epimedin A1, epimedin A, epimedin B, epimedin C, icariin, baohuosideⅡ, icarisideⅠ, sagittatoside B, 2"-O-rhamnosyl icarisideⅡ, and baohuosideⅠin epimedium total flavone capsule. At the same time, the effects of the above 11 compounds on osteogenic differentiation of MC3T3-E1 cells were investigated by detecting the content of alkaline phosphatase (AKP). The results showed that baohuoside Ⅱ had the highest activities, and both the activities of baohuoside Ⅱ and icariside Ⅰ were stronger than those of icariin.In this study, the content determination method of flavonoid glycosides was established, and the anti-osteoporosis effect of monomers was compared, providing technical support for the study of the pharmacodynamic and mechanism of Epimedium total flavone capsule.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP140147779	Epimedin A1		140147-77-9	Price

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