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Determination of Isoetharine in Plasma by Reversed-Phase Chromatography With Amperometric Detection

G B Park, R F Koss, J Utter, B A Mayes, J Edelson

J Pharm Sci. 1982 Aug;71(8):932-4.

PMID: 7120101

Abstract:

A reversed-phase liquid chromatographic method for the determination of isoetharine in blood plasma, utilizing amperometric detection, is described. Plasma samples were extracted utilizing an ion-pair reagent, di-(2-ethylhexyl)phosphoric acid, to concentrate the catecholamine. Only minor differences were observed in the relative bioavailability of isoetharine hydrochloride and isoetharine mesylate after oral administration to rats. Observed plasma levels, at 1 hr after oral medication, were highly variable in dose-ranging studies at doses of 800-2500 mg/kg/day for 2 weeks.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2576923 Isoetharine hydrochloride Isoetharine hydrochloride 2576-92-3 Price
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