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[Determination of Methcathinone in Urine by GC-MS]

[Determination of Methcathinone in Urine by GC-MS]

D X Liu, M M Zhao

Fa Yi Xue Za Zhi. 2017 Oct;33(5):506-508.

PMID: 29275556

Abstract:

Objectives:
To establish a method for the analysis of methcathinone in urine by gas chromatography-mass spectrometry (GC-MS).
Methods:
Proadifen hydrochloride (internal standard) and buffer solution (pH=9) were added into the urine samples, and methcathinone was extracted by ethyl acetate. The extract was volatilized in 50 ℃ nitrogen gas flow and the remnant was dissolved by methanol and analysed by GC-MS.
Results:
The methcathinone in urine showed a good linear relationship in the mass concentration range of 0.02-2.00 μg/mL. The linear equation was y=0.301 9 x+0.018 9 (r=0.999 2), and the detection limit was 0.01 μg/mL. The recoveries of methcathinone in urine was 96.4%-99.2%, with the intra-day precision of 5.8%-7.6% and the inter-day precision of 6.0%-8.1%.
Conclusions:
The method is convenient and sensitive, which can be applied to the forensic identification of methcathinone in urine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP152610690	R(+)-Methcathinone hydrochloride solution		152610-69-0	Price

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