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Determination of N-nitrosodiethanolamine in Cosmetic Products by Headspace Solid Phase Microextraction Using a Novel Aluminum Hydroxide Grafted Fused Silica Fiber Followed by Gas Chromatography-Mass Spectrometry Analysis

Determination of N-nitrosodiethanolamine in Cosmetic Products by Headspace Solid Phase Microextraction Using a Novel Aluminum Hydroxide Grafted Fused Silica Fiber Followed by Gas Chromatography-Mass Spectrometry Analysis

Saied Saeed Hosseiny Davarani, Leila Masoomi, Mohammad Hossein Banitaba, Hamid Reza Lotfi Zadeh Zhad, Omid Sadeghi, Azam Samiei

Talanta. 2013 Feb 15;105:347-53.

PMID: 23598029

Abstract:

A method based on headspace solid phase microextraction with a new fiber, coupled with gas chromatography-mass spectrometry was developed for the determination of NDELA in cosmetic samples. The fiber provides Lewis acid-base interaction between its surface and analyte functional groups. The fiber was prepared by grafting aluminum tri-tert-butoxide on the surface of a fused silica. The optimization of SPME conditions showed that NDELA can be most effectively extracted at 70°C, in 15 min, with a sample volume of 0.5 (Vs/Vt), stirring rate of 150 rpm, desorption time of 5 min, desorption temperature of 260°C and at 12.5% (w/w) concentration of NaCl. Under the optimized conditions, LOD of 1 μg Kg(-1) and a calibration curve with correlation coefficients greater than 0.9897 and a linearity range from 6 to 10000 μg Kg(-1) were obtained. The intra-day and inter-day precision and accuracy were evaluated at four concentration levels. All of the values for accuracy and precision were lower than the acceptable limit of 15%. The fiber to fiber repeatability was 8.7%. The method was applied for the analysis of real samples including hair shampoo, body shampoo, dishwashing liquid and hand washing liquid. Relative recoveries were achieved in the range of 95-99%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP556912	Aluminum tert-butoxide		556-91-2	Price

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