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Determination of Potassium Guaiacolsulfonate by Ion-Pairing Partition Chromatography

T D Doyle, J B Proctor

J Assoc Off Anal Chem. 1975 Mar;58(2):276-82.

PMID: 237875

Abstract:

Potassium guaiacolsulfonate, a highly polar, acidic substance, is readily eluted by chloroform from a pH 4.5 Celite column in the form of its ion-pair with trihexylamine, thereby effecting facile separation from other pharmaceuticals. The sulfonic acid is then back-extracted into aqueous alkali and determined spectrophotometrically. Assay of standard solutions by this procedre averaged 100.44 plus or minus 0.81%. The method was applied successfully to 4 commercial cough preparations containing a variety of other drugs.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP78247491 Potassium guaiacolsulfonate Potassium guaiacolsulfonate 78247-49-1 Price
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