Home
Resources
Publications
[Determination of Stachydrine Hydrochloride and Leonurine Hydrochloride in Yimucao Preparations by HPLC-MS]

[Determination of Stachydrine Hydrochloride and Leonurine Hydrochloride in Yimucao Preparations by HPLC-MS]

Chao Zhou, Yi He, Yu-Mei Zhang, Bo Wang, Jian-Dong Yu, Zhong Dai, Shuang-Cheng Ma

Zhongguo Zhong Yao Za Zhi. 2016 May;41(10):1876-1879.

PMID: 28895336

Abstract:

To establish the quantitative method of stachydrine hydrochloride and leonurine hydrochloride in the preparations of Leonuri Herba. The contents of stachydrine hydrochloride and leonurine hydrochloride in the preparations of Leonuri Herba were determined by HPLC-MS. The chromatographic column was Waters XBridge Amide(4.6 mm×250 mm,5 μm). The mobile phase was acetonitrile-0.1% formic acid in gradient mode,at the flow rate of 1.0 mL• min⁻¹,with the split ratio of 1∶4. MS conditions for the ESI ion source,positive ion mode,selective ion scan(SIM) of stachydrine hydrochloride(m/z 144.0) and leonurine hydrochloride(m/z 312.0) was measured. The linear ranges of stachydrine hydrochloride was 0.562 8-281.4 μg•L-1(r=0.999 8). The linear ranges of leonurine hydrochloride was 0.521 2-260.6 μg•L-1(r=0.999 8). The method is accurate,simple,and reliable,and can be used to determine the contents of stachydrine hydrochloride and leonurine hydrochloride in the preparations of Leonuri Herba.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24735180	Leonurine hydrochloride		24735-18-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: