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Determination of tris(2-ethylhexyl)trimellitate Released From PVC Tube by LC-MS/MS

Determination of tris(2-ethylhexyl)trimellitate Released From PVC Tube by LC-MS/MS

Rie Ito, Naoko Miura, Hirofumi Iguchi, Hiroko Nakamura, Masaru Ushiro, Nobuyuki Wakui, Keisuke Nakahashi, Yusuke Iwasaki, Koichi Saito, Tsutomu Suzuki, Hiroyuki Nakazawa

Int J Pharm. 2008 Aug 6;360(1-2):91-5.

PMID: 18502595

Abstract:

Tris(2-ethylhexyl)trimellitate (TOTM) is used as an alternative plasticizer of polyvinyl chloride (PVC) medical devices. A method for the determination of TOTM released from PVC medical devices into intravenous preparations was developed, which uses liquid chromatography-tandem mass spectrometry (LC-MS/MS). A PVC tube was filled with an intravenous preparation and extraction was carried out by shaking for 1h at room temperature. LC was performed with an Inertsil-C8 (50 mm x 2.1 mm, 5 microm) column. The isocratic mobile phase was acetonitrile:purified water (90:10, v/v) at a flow rate of 0.2 ml/min. MS detection was accomplished with an MS/MS detector equipped with a turbo ionspray ionization source in the positive ion mode. The limit of detection and the limit of quantification for the standard solution of TOTM was 0.5 ng/ml (S/N=3) and 1.0 ng/ml (S/N > or =10), respectively. When Prograf (tacrolimus) was used, the average recovery of TOTM was 101.1% (R.S.D.=4.72%; n=3). When our method was applied to the determination of TOTM released from unsterilized and gamma-ray-sterilized PVC tubes, we found that a higher concentration of TOTM was released from the unsterilized PVC tube than from the gamma-ray-sterilized one.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3319311	Tris(2-ethylhexyl) trimellitate		3319-31-1	Price

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