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Detoxification of Fusaric Acid by the Soil Microbe Mucor Rouxii

Detoxification of Fusaric Acid by the Soil Microbe Mucor Rouxii

Frankie K Crutcher, Lorraine S Puckhaber, Alois A Bell, Jinggao Liu, Sara E Duke, Robert D Stipanovic, Robert L Nichols

J Agric Food Chem. 2017 Jun 21;65(24):4989-4992.

PMID: 28538103

Abstract:

Fusarium oxysporum f. sp. vasinfectum race 4 (VCG0114), which causes root rot and wilt of cotton (Gossypium hirsutum and G. barbadense), has been identified recently for the first time in the western hemisphere in certain fields in the San Joaquin Valley of California. This pathotype produces copious quantities of the plant toxin fusaric acid (5-butyl-2-pyridinecarboxylic acid) compared to other isolates of F. oxysporum f. sp. vasinfectum (Fov) that are indigenous to the United States. Fusaric acid is toxic to cotton plants and may help the pathogen compete with other microbes in the soil. We found that a laboratory strain of the fungus Mucor rouxii converts fusaric acid into a newly identified compound, 8-hydroxyfusaric acid. The latter compound is significantly less phytotoxic to cotton than the parent compound. On the basis of bioassays of hydroxylated analogues of fusaric acid, hydroxylation of the butyl side chain of fusaric acid may affect a general detoxification of fusaric acid. Genes that control this hydroxylation may be useful in developing biocontrol agents to manage Fov.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP536696	Fusaric acid		536-69-6	Price

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