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Development and Characterization of Morin Hydrate-Loaded Micellar Nanocarriers for the Effective Management of Alzheimer's Disease

Manpreet Singh, Vandana Thakur, Rahul Deshmukh, Amit Sharma, M S Rathore, Ajay Kumar, Neeraj Mishra

J Microencapsul. 2018 Mar;35(2):137-148.

PMID: 29448848

Abstract:

The aim of this study was to prepare and characterise oral delivery of morin hydrate-loaded micellar nanocarriers using Pluronic P127 and Pluronic F123 for the effective management of Alzheimer's disease. After administration of formulation brain and blood drug concentration were found to be highest for optimised morin hydrate-loaded micellar nanocarriers as compared to plain morin hydrate. Significant (p < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate-loaded micellar nanocarriers as compared to disease control group. Chronic treatment with morin-loaded micelles significantly increased the memory in AlCl3 induced Alzheimer's disease in Wistar rats.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP654055013 Morin hydrate Morin hydrate 654055-01-3 Price
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