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Development and Evaluation of Dexamethasone Nanomicelles With Potential for Treating Posterior Uveitis After Topical Application

Development and Evaluation of Dexamethasone Nanomicelles With Potential for Treating Posterior Uveitis After Topical Application

Soohi Patel, Chandrasekhar Garapati, Pallabita Chowdhury, Himanshu Gupta, Jerry Nesamony, Surya Nauli, Sai H S Boddu

J Ocul Pharmacol Ther. 2015 May;31(4):215-27.

PMID: 25839185

Abstract:

Purpose:
This study aims at the development and preliminary evaluation of dexamethasone nanomicelles for treating posterior uveitis. Nanomicelles were formulated using polyoxyl 40 stearate (P40S) and polysorbate 80 (P80), which are approved by the FDA for ocular use.
Methods:
Dexamethasone nanomicelles were prepared and characterized for critical micellar concentration, solubility of dexamethasone, particle size, surface charge, morphology, in vitro drug release, clarity, stability, filtration efficiency, and sterility. Ocular tolerance and the tissue drug distribution of dexamethasone were assessed in rabbits after single and multiple topical administration.
Results:
Dexamethasone nanomicelles (0.1% w/v) were successfully developed and characterized with an optimized composition of P40S/P80=7/3 by weight. The mean diameter of blank and drug-loaded nanomicelles was 13.3±0.4 and 14.5±0.4 nm, respectively. Transmission electron microscopy images revealed the spherical structure of nanomicelles. Nanomicelles were found to be stable with respect to clarity, size and drug content at 4°C and 25°C for up to 6 months. No irritation or redness was observed in the treated eyes as compared with the untreated control rabbit eyes. Therapeutic concentrations of dexamethasone were observed in the retina and choroid after single and multiple topical application in rabbits.
Conclusion:
In conclusion, the nanomicelles of P40S and P80 could efficiently solubilize 0.1% dexamethasone in their cores. The results also indicate that mixed nanomicelles could be utilized as a potential delivery system for delivering dexamethasone to treat the back of the eye diseases such as posterior uveitis after topical application.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004993-B	Polyoxyl 40 stearate		9004-99-3	Price
AP9004993-C	Polyoxyl 6 stearate		9004-99-3	Price

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