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Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease

Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease

Li Zhang, Yuemeng Huang, Meng Wang, Yafen Guo, Jing Liang, Xiurong Yang, Wenjing Qi, Yanjun Wu, Jinglei Si, Siran Zhu, Zhe Li, Ruiqiang Li, Chao Shi, Shuo Wang, Qunjie Zhang, Zhonglin Tang, Lixian Wang, etc.

iScience. 2019 Sep 27;19:162-176.

PMID: 31376679

Abstract:

Pig has been proved to be a valuable large animal model used for research on diabetic disease. However, their translational value is limited given their distinct anatomy and physiology. For the last 30 years, we have been developing a laboratory Asian miniature pig inbred line (Bama miniature pig [BM]) from the primitive Bama xiang pig via long-term selective inbreeding. Here, we assembled a BM reference genome at full chromosome-scale resolution with a total length of 2.49 Gb. Comparative and evolutionary genomic analyses identified numerous variations between the BM and commercial pig (Duroc), particularly those in the genetic loci associated with the features advantageous to diabetes studies. Resequencing analyses revealed many differentiated gene loci associated with inbreeding and other selective forces. These together with transcriptome analyses of diabetic pig models provide a comprehensive genetic basis for resistance to diabetogenic environment, especially related to energy metabolism.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61417467	Deamino-Tyr-β-Ala-secretin, pig		61417-46-7	Price

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