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Development and in Vitro Evaluation of Solid Dispersions as Strategy to Improve Albendazole Biopharmaceutical Behavior

Development and in Vitro Evaluation of Solid Dispersions as Strategy to Improve Albendazole Biopharmaceutical Behavior

Analía Simonazzi, Alicia Graciela Cid, Alejandro Javier Paredes, Laureano Schofs, Elio Emilio Gonzo, Santiago Daniel Palma, José María Bermúdez

Ther Deliv. 2018 Sep;9(9):623-638.

PMID: 30189808

Abstract:

Aim:
Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles.
Methods:
ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation.
Results:
Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence. Solid dispersions initial dissolution rate was three to 20-fold higher than physical mixtures, the drug and the commercial formulation. All the solid dispersions required less than 2.2 min to reach an 80% of ABZ dissolution, while the commercial formulation needed around 40 min.
Conclusion:
Solid dispersions improved ABZ solubility and dissolution rate, which could result in a faster absorption and an increased bioavailability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003116-C	Poloxamer solid		9003-11-6	Price

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