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Development and Optimization of a Fluorescent Imaging System to Detect Amyloid-β Proteins: Phantom Study

Development and Optimization of a Fluorescent Imaging System to Detect Amyloid-β Proteins: Phantom Study

David Tes, Karl Kratkiewicz, Ahmed Aber, Luke Horton, Mohsin Zafar, Nour Arafat, Afreen Fatima, Mohammad Rn Avanaki

Biomed Eng Comput Biol. 2018 Jun 18;9:1179597218781081.

PMID: 29977121

Abstract:

Alzheimer disease is the most common form of dementia, affecting more than 5 million people in the United States. During the progression of Alzheimer disease, a particular protein begins to accumulate in the brain and also in extensions of the brain, ie, the retina. This protein, amyloid-β (Aβ), exhibits fluorescent properties. The purpose of this research article is to explore the implications of designing a fluorescent imaging system able to detect Aβ proteins in the retina. We designed and implemented a fluorescent imaging system with a range of applications that can be reconfigured on a fluorophore to fluorophore basis and tested its feasibility and capabilities using Cy5 and CRANAD-2 imaging probes. The results indicate a promising potential for the imaging system to be used to study the Aβ biomarker. A performance evaluation involving ex vivo and in vivo experiments is planned for future study.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1193447345	CRANAD 2		1193447-34-5	Price

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