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Development of Selective Inhibitors of Necrosis

Development of Selective Inhibitors of Necrosis

Mikiko Sodeoka, Kosuke Dodo

Chem Rec. 2010 Oct;10(5):308-14.

PMID: 20848666

Abstract:

Oxidative stress-induced necrosis plays an important role in ischemia-reperfusion injury, such as stroke and heart attack. Here, we describe the development of selective inhibitors of necrosis, MS-1 and IM-54, as potential cardioprotective agents and biological tools for investigating the molecular mechanisms of cell death. By means of chemical modifications of kinase inhibitor BM I, its affinity for various kinases was successfully removed and a potent and selective inhibitor of necrosis, IM-54, was obtained. IM-54 inhibits necrosis induced by oxidative stress, but not apoptosis induced by anticancer drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP861891501	IM-54		861891-50-1	Price

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