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Development of Small-Molecule Inhibitors Targeting Adipose Triglyceride Lipase

Nicole Mayer, Martina Schweiger, Matthias Romauch, Gernot F Grabner, Thomas O Eichmann, Elisabeth Fuchs, Jakov Ivkovic, Christoph Heier, Irina Mrak, Achim Lass, Gerald Höfler, Christian Fledelius, Rudolf Zechner, etc.

Nat Chem Biol. 2013 Dec;9(12):785-7.

PMID: 24096302

Abstract:

Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4247101 Atglistatin Atglistatin Price
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