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Diagnostic Performances of Hepatitis C virus-NS4 Antigen in Patients With Different Liver Pathologies

Diagnostic Performances of Hepatitis C virus-NS4 Antigen in Patients With Different Liver Pathologies

Abdelfattah M Attallah, Mohamed M Omran, Wesam A Nasif, Mohamed F Ghaly, Abd El-Raheem R El-Shanshoury, Mohga S Abdalla, Hayat M Sharada, Khaled Farid, Wageh El-Shony, El-Sayed M Moussa, Ehab B El-Domany, etc.

Arch Med Res. 2012 Oct;43(7):555-62.

PMID: 23085447

Abstract:

Background and aims:
Hepatitis C virus (HCV) has emerged as the major pathogen of liver disease worldwide. The aim of this study was to quantitate and evaluate the performance of HCV-NS4 antigen as an alternative approach for confirmation of viremia.
Methods:
Detection of HCV-NS4 was assessed in 883 patients with chronic hepatitis C. Areas under the ROC curves (AUC) were used to assess and compare diagnostic accuracy of ELISA for HCV-NS4 with quantitative HCV-RNA as a gold standard.
Results:
HCV-NS4 was identified at 27 kDa using Western blot. AUC for HCV-NS4 detection was 0.95 for all patients with different liver pathologies: 0.93 for liver fibrosis (LF), 0.95 for liver cirrhosis (LC) and 0.98 for hepatocellular carcinoma (HCC). The mean ± SD (μg/mL) of HCV-NS4 in LF was 94.2 ± 55.6; in LC was 99.3 ± 64.8 and in HCC was 124.9 ± 70.3.
Conclusions:
HCV-NS4 antigen detection using ELISA is a reliable test in the confirmation of HCV infection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414632	Hepatitis C virus NS4 antigen			Price

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