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Diethylenetriaminepentaacetic Acid-Gadolinium (DTPA-Gd)-conjugated Polysuccinimide Derivatives as Magnetic Resonance Imaging Contrast Agents

Diethylenetriaminepentaacetic Acid-Gadolinium (DTPA-Gd)-conjugated Polysuccinimide Derivatives as Magnetic Resonance Imaging Contrast Agents

Ha Young Lee, Hye Won Jee, Sung Mi Seo, Byung Kook Kwak, Gilson Khang, Sun Hang Cho

Bioconjug Chem. May-Jun 2006;17(3):700-6.

PMID: 16704207

Abstract:

Biocompatible polysuccinimide (PSI) derivatives conjugated with diethylenetriaminepentaacetic acid gadolinium (DTPA-Gd) were prepared as magnetic resonance imaging (MRI) contrast agents. In this study, we synthesized PSI derivatives incorporating methoxy-poly(ethylene glycol) (mPEG) as hydrophilic ligand, hexadecylamine as hydrophobic ligand, and DTPA-Gd as contrast agent. PSI was synthesized by the polycondensation polymerization of aspartic acid. All the synthesized materials were characterized by proton nuclear magnetic resonance (1H NMR). Critical micellization concentrations were determined using fluorescent probes (pyrene). Micelle size and shape were measured by electro-photometer light scattering (ELS) and atomic force microscopy (AFM). The formed micelle size ranged from 100 to 300 nm. The T1-weighted MR images of the phantom prepared with PSI-mPEG-C16-(DTPA-Gd) were obtained in a 3.0 T clinical MR imager, and the conjugates showed a great potential as MRI contrast agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7411239	Methoxypolyethylene glycol pyrene			Price

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