Home
Resources
Publications
Differences in the Interactions of a Monoglyceride With Cholesterol and With a Bile Salt

Differences in the Interactions of a Monoglyceride With Cholesterol and With a Bile Salt

Shinichiro Sato, Cathy E McNamee

Colloids Surf B Biointerfaces. 2014 May 1;117:144-51.

PMID: 24632387

Abstract:

The differences in the interaction of monoglycerides with bile acids or cholesterol have been investigated from a physico-chemical point of view. A Langmuir trough and fluorescence microscope was used to study mixed monolayers of DL-α-palmitin (a monoglyceride) and cholesterol or deoxycholic acid (a bile acid) at the air/aqueous interface. The surface pressure-area per molecule isotherms of the monolayers were analyzed to give the thermodynamic properties. The deoxycholic acid-DL-α-palmitin monolayer showed stronger repulsions between the film components than was observed with the cholesterol acid-DL-α-palmitin monolayer. Mixed monolayers containing DL-α-palmitin and cholesterol or deoxycholic acid phase separated at high surface pressures and high fractions of DL-α-palmitin, the conditions that resulted in the most repulsions between the two components of the monolayer. The mixed cholesterol and DL-α-palmitin monolayer phase separated in a random pattern. The deoxycholic acid and DL-α-palmitin mixed monolayer gave smaller domains that were distributed in a homogeneous fashion within the monolayer at high molecular packing densities. The difference in the cholesterol and deoxycholic acid interactions with DL-α-palmitin were explained by the fact that while both cholesterol and deoxycholic acid molecules do not pack efficiently with the DL-α-palmitin molecules, the attractive interactions between the alcohol groups on DL-α-palmitin and the carboxylic groups on deoxycholic acid cause attractive interactions between the deoxycholic acid and DL-α-palmitin domains, which causes the interaction abilities of deoxycholic acid with DL-α-palmitin to be higher than cholesterol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP542449	DL-α-Palmitin		542-44-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: