Home
Resources
Publications
Differential Effects of High-Fat-Diet Rich in Lard Oil or Soybean Oil on Osteopontin Expression and Inflammation of Adipose Tissue in Diet-Induced Obese Rats

Differential Effects of High-Fat-Diet Rich in Lard Oil or Soybean Oil on Osteopontin Expression and Inflammation of Adipose Tissue in Diet-Induced Obese Rats

Xiaoke Wang, Mengjie Cheng, Min Zhao, Aiguo Ge, Fangfang Guo, Min Zhang, Yanhong Yang, Liegang Liu, Nianhong Yang

Eur J Nutr. 2013 Apr;52(3):1181-9.

PMID: 22847642

Abstract:

Purpose:
To examine the effect of different dietary fat types on osteopontin (OPN) expressions and inflammation of adipose tissues in diet-induced obese rats.
Methods:
Male Sprague-Dawley rats were randomly assigned to one control group fed standard diet (LF, n = 10) and two high-fat diet groups fed isoenergy diet rich in lard or soybean oil (HL or HS, n = 45 each). Diet-induced obese rats in HL and HS group were then subdivided into two groups either continuously fed high-fat diet or switched to low-fat diet for 8 more weeks. Fasting serum glucose, insulin, and OPN concentrations were assayed and QUICKI was calculated; the expression of OPN, IL-6, IL-10, TNF-α, NF-κB, and F4/80 in adipose tissue was determined.
Results:
Both high-fat diets lead to comparable development of obesity characterized by insulin resistance and adipose tissue inflammation. Obese rats continuously fed high-fat diet rich in lard oil exhibited the highest fasting serum insulin level and adipose tissue OPN, F4/80, TNF-α, and NF-κB expression level. In both high-fat diet groups, switching to low-fat diet resulted in less intra-abdominal fat mass, decreased expression of F4/80, TNF-α, and NF-κB, while decreased OPN expression was only observed in lard oil fed rats after switching to low-fat diet.
Conclusions:
Reducing diet fat or replacing lard oil with soybean oil in high-fat diet alleviates obesity-related inflammation and insulin resistance by attenuating the upregulation of OPN and macrophage infiltration into adipose tissue induced by high-fat diet.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP8016282	Lard oil		8016-28-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: