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Differential Effects of Omega-Conotoxin GVIA and MVIIC on Nerve Stimulation Induced Contractions of Guinea-Pig Ileum and Rat Vas Deferens

J R Boot

Eur J Pharmacol. 1994 Jun 2;258(1-2):155-8.

PMID: 7925595

Abstract:

omega-Conotoxin GVIA and omega-conotoxin MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The inhibitory effects of omega-conotoxin GVIA were long-lasting whereas those to omega-conotoxin MVIIC were readily reversed. Preincubation with omega-conotoxin MVIIC prevented the irreversible inhibition of omega-conotoxin GVIA suggesting a common site of interaction. However, unlike omega-conotoxin GVIA which caused inhibition, omega-conotoxin MVIIC did not affect the electrically induced twitch responses of the rat vas deferens nor did it prevent the irreversible inhibition with omega-conotoxin GVIA. This study indicates the possible existence of different subtypes of the N-type voltage-dependent calcium channel.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP147794238 ω-Conotoxin MVIIC ω-Conotoxin MVIIC 147794-23-8 Price
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