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Differential Pulse Voltammetric Determination of Metformin Using Copper-Loaded Activated Charcoal Modified Electrode

Differential Pulse Voltammetric Determination of Metformin Using Copper-Loaded Activated Charcoal Modified Electrode

Mohammad Bagher Gholivand, Leila Mohammadi-Behzad

Anal Biochem. 2013 Jul 1;438(1):53-60.

PMID: 23541522

Abstract:

A simple and sensitive carbon paste electrode has been developed for the electrochemical trace determination of metformin (MET). This sensor was designed by Copper(II)-loaded activated charcoal (Cu-AC) in the carbon paste electrode (CPE), which provides remarkably improved sensitivity and selectivity for the electrochemical stripping assay of MET. The drug was accumulated on the surface of the electrode through formation of a coordination complex with copper ions, which enhanced the sensitivity of the method. The effects of various copper(II) salts and oxidation states of copper (within the carbon paste electrode) on MET oxidation behavior were also investigated. The calibration graph was linear over the concentration range of 50 nM to 60 μM MET, and the detection limit was calculated as 9 nM. The proposed electrode was used successfully for MET determination in real matrices.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS21104	Trace Metals - Activated Charcoal			Price

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