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Dihydrochalcones From Piper Longicaudatum

Dihydrochalcones From Piper Longicaudatum

A S Joshi, X C Li, A C Nimrod, H N elSohly, L A Walker, A M Clark

Planta Med. 2001 Mar;67(2):186-8.

PMID: 11301876

Abstract:

Bioactivity-guided fractionation of an ethanolic extract of the leaves and twigs of Piper longicaudatum Trelease & Yunker (Piperaceae) resulted in the isolation of one new (1) and three known (2-4) dihydrochalcones. The known compounds are: 2',6'-dihydroxy-4'-methoxydihydrochalcone (2), 2',6',4-trihydroxy-4'-methoxydihydrochalcone (asebogenin) (3), and 2'-hydroxy-4'-methoxy-2'-[1-hydroxy-1-methylethyl]-2",3"-dihy- drofurano[4",5":5',6"]-3"-[2-hydroxy-5-methoxycarbonylphe- nyl]dihydrochalcone (piperaduncin B) (4). The new compound is 2'-hydroxy-4'-methoxy-2"-[2-hydroxy-5-methoxycarbonyl- phenyl]-furano[4",5":5',6']-dihydrochalcone (longicaudatin) (1). Compounds 1-4 were tested for antibacterial activity against S. aureus and methicillin-resistant S. aureus (MRSA); only compound 3 showed inhibitory activity (IC50 of 10 and 4.5 micrograms/ml, respectively).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35241555	2′,6′-Dihydroxy 4′-methoxydihydrochalcone		35241-55-5	Price

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