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Dihydrochalcones With Antiinflammatory Activity From Leaves and Twigs of Cyathostemma Argenteum

Dihydrochalcones With Antiinflammatory Activity From Leaves and Twigs of Cyathostemma Argenteum

Jariya Somsrisa, Puttinan Meepowpan, Samroeng Krachodnok, Haruthai Thaisuchat, Sittiporn Punyanitya, Narong Nantasaen, Wilart Pompimon

Molecules. 2013 Jun 10;18(6):6898-907.

PMID: 23752472

Abstract:

A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed signiﬁcant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35241544	2′,6′-Dihydroxy 4′,4-dimethoxydihydrochalcone		35241-54-4	Price

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