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Diphtheria in Belgium: 2010-2017

Diphtheria in Belgium: 2010-2017

Helena Martini, Oriane Soetens, David Litt, Norman K Fry, Liselot Detemmerman, Ingrid Wybo, Isabelle Desombere, Androulla Efstratiou, Denis Piérard

J Med Microbiol. 2019 Oct;68(10):1517-1525.

PMID: 31418673

Abstract:

In Western Europe, the incidence of both respiratory and cutaneous diphtheria, caused by toxin-producing Corynebacterium diphtheriae, Corynebacterium ulcerans or Corynebacterium pseudotuberculosis, has been low over the past few decades thanks to the use of an effective vaccine and a high level of vaccination coverage. However, the disease has still not been eradicated and continues to occur in all of Europe. In order to prevent sequelae or a fatal outcome, diphtheria antitoxin (DAT) should be administered to suspected diphtheria patients as soon as possible, but economic factors and issues concerning regulations have led to poor availability of DAT in many countries. The European Centre for Disease Prevention and Control and World Health Organization have called for European Union-wide solutions to this DAT-shortage. In order to illustrate the importance of these efforts and underline the need for continued diphtheria surveillance, we present data on all registered cases of toxigenic and non-toxigenic C. diphtheriae, C. ulcerans and C. pseudotuberculosis in Belgium during the past decade, up to and including 2017.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4243053	Diphtheria Toxin from Corynebacterium diphtheriae			Price

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