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Direct Chemiluminescence Determination of Penicillin G Potassium and a Chemometrical Optimization Approach

Direct Chemiluminescence Determination of Penicillin G Potassium and a Chemometrical Optimization Approach

Mohammad H Sorouraddin, Mortaza Iranifam, Abdolhossein Naseri, Mohammad Fadakar-Sardroud, Hossein Gharari-Alibabalou

Luminescence. Nov-Dec 2011;26(6):622-8.

PMID: 21465632

Abstract:

A highly selective and simple chemiluminescence (CL) method for determination of penicillin G potassium (PGK) was developed. In the proposed method, CL was elicited from PGK upon its oxidation with H(2)O(2). The light emission was enhanced in the presence of N-cetyl-N,N,N-trimethylammonium bromide (CTMAB). An experimental design, central composite design (CCD), was used to realize the optimized variables, including pH, surfactant (CTMAB) and H(2)O(2) concentrations. Under optimum condition, the calibration graph was linear in the range 3.3 × 10(-3) -3.3 × 10(-1) mmol/L, with a detection limit of 8.8 × 10(-4) mmol/L for PGK. The precision was calculated by analysing samples containing 1.6 × 10(-1) mmol/L PGK (n = 5) and the relative standard deviation (RSD) was 1.40%. The utility of this method was demonstrated by determining PGK in pharmaceutical formulations for injection. The proposed method was validated by a reference method.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP113984-B	Penicillin G potassium		113-98-4	Price

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