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Direct Dehydroxytrifluoromethylthiolation of Alcohols Using silver(I) Trifluoromethanethiolate and Tetra-N-Butylammonium Iodide

Jian-Bo Liu, Xiu-Hua Xu, Zeng-Hao Chen, Feng-Ling Qing

Angew Chem Int Ed Engl. 2015 Jan 12;54(3):897-900.

PMID: 25420412

Abstract:

An unprecedented reaction for the direct trifluoromethylthiolation and fluorination of alkyl alcohols using AgSCF3 and nBu4NI has been developed. The trifluoromethylthiolated compounds and alkyl fluorides were selectively formed by changing the ratio of AgSCF3/nBu4NI. This protocol is tolerant of different functional groups and might be applicable to late-stage trifluoromethylthiolation of alcohols.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP36945081 n-Butylammonium iodide n-Butylammonium iodide 36945-08-1 Price
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