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Direct Evidence of Facilitative Actions of Dopamine in the Medial Preoptic Area on Reflexive and Noncontact Erections in Male Rats

Direct Evidence of Facilitative Actions of Dopamine in the Medial Preoptic Area on Reflexive and Noncontact Erections in Male Rats

Hideki Adachi, Yoshikazu Sato, Ryuichi Kato, Shinichi Hisasue, Kazuhiro Suzuki, Naoya Masumori, Naoki Itoh, Taiji Tsukamoto

J Urol. 2003 Jan;169(1):386-9.

PMID: 12478196

Abstract:

Purpose:
We examined the effects of alterations of the extracellular dopamine level in the medial preoptic area on 2 erectile contexts, namely reflexive and noncontact erections, in male rats.
Materials and methods:
The extracellular dopamine level was measured in the medial preoptic area after administering the dopamine reuptake inhibitor bupropion hydrochloride (Sigma Chemical Co., St. Louis, Missouri) into the same area through a micro-dialysis tube. We measured the frequency and latency of reflexive erections, and the frequency of noncontact erection during infusion of bupropion.
Results:
Administration of 10 mM. bupropion was associated with significant elevation in the extracellular dopamine level in the medial preoptic area. Bupropion (1 mM.) and Ringer's solution did not induce significant alterations in dopamine in the medial preoptic area. The number of reflexive erections significantly increased and erection latency decreased during infusion of 10 mM. bupropion into the medial preoptic area. The number of noncontact erections was also increased by administering 10 mM. of drug.
Conclusions:
The altered dopamine level in the medial preoptic area affected 2 distinct penile erectile contexts, suggesting that the dopamine levels in the medial preoptic area may be involved in the regulation of erection. These results may have important implications for the central regulation of penile erection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31677937-A	Bupropion hydrochloride solution		31677-93-7	Price

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