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Direct Hiyama Cross-Coupling of Enaminones With Triethoxy(aryl)silanes and Dimethylphenylsilanol

Lei Bi, Gunda I Georg

Org Lett. 2011 Oct 21;13(20):5413-5.

PMID: 21939201

Abstract:

2,3-Dihydropyridin-4(1H)-ones undergo direct C-H functionalization at C5 in the palladium(II)-catalyzed Hiyama reaction, using triethoxy(aryl)silanes and dimethylphenylsilanol. The reagent CuF(2) has a dual role in the reactions with triethoxy(aryl)silanes. It is a source of fluoride to activate the silane in the Hiyama reaction and also serves as the reoxidant to convert Pd(0) to Pd(II) in the catalytic cycle.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP5272184 Dimethylphenylsilanol Dimethylphenylsilanol 5272-18-4 Price
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