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Discovery of Novel (1S)-(-)-verbenone Derivatives With Anti-Oxidant and Anti-Ischemic Effects

Discovery of Novel (1S)-(-)-verbenone Derivatives With Anti-Oxidant and Anti-Ischemic Effects

Chung Ju, Sumi Song, Sunyoung Hwang, Chorong Kim, Minkyoung Kim, Jail Gu, Yu-Kyoung Oh, Kyeong Lee, Jinsun Kwon, Kiho Lee, Won-Ki Kim, Yongseok Choi

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5421-5.

PMID: 23953190

Abstract:

A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1196016	(1S)-(−)-Verbenone		1196-01-6	Price

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