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Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA(1)/GPR40), a Potential Target for the Treatment of Type II Diabetes

Elisabeth Christiansen, Christian Urban, Nicole Merten, Kathrin Liebscher, Kasper K Karlsen, Alexandra Hamacher, Andreas Spinrath, Andrew D Bond, Christel Drewke, Susanne Ullrich, Matthias U Kassack, Evi Kostenis, etc.

J Med Chem. 2008 Nov 27;51(22):7061-4.

PMID: 18947221

Abstract:

A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1082058998 TUG-424 TUG-424 1082058-99-8 Price
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