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Discussion of the Role of the Extracellular Signal-Regulated Kinase-Phospholipase A2 Pathway in Production of Reactive Oxygen Species in Alzheimer's Disease

Discussion of the Role of the Extracellular Signal-Regulated Kinase-Phospholipase A2 Pathway in Production of Reactive Oxygen Species in Alzheimer's Disease

Jannike M Andersen, Oddvar Myhre, Frode Fonnum

Neurochem Res. 2003 Feb;28(2):319-26.

PMID: 12608704

Abstract:

In this paper we show that exposure of a rat brain synaptosome fraction to the amyloid beta peptide fragment betaA(25-35), but not the inverted peptide betaA(35-25), stimulated production of reactive oxygen species (ROS) in a concentration- and time-dependent manner. The ROS formation was attenuated by the tyrosine kinase inhibitor genistein, the mitogen-activated protein kinase inhibitor U0126, and the phospholipase A2 (PLA2) inhibitor 7,7-dimethyl-(5Z,8Z)-eicosadienoic acid. This strongly suggests that betaA(25-35) stimulated ROS production through an extracellular signal-regulated kinase-PLA2-dependent pathway. The interaction between these enzymes and their possible involvement in free radical formation in Alzheimer's disease are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP89560010	7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid		89560-01-0	Price

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