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Disposition of Ampiroxicam, a Prodrug of Piroxicam, in Man

Disposition of Ampiroxicam, a Prodrug of Piroxicam, in Man

F C Falkner, T M Twomey, A P Borgers, D Garg, D Weidler, N Gerber, I W Browder

Xenobiotica. 1990 Jun;20(6):645-52.

PMID: 2219958

Abstract:

1. Ampiroxicam, a prodrug of the effective anti-inflammatory agent piroxicam, was completely converted to piroxicam after oral administration to man. 2. At clinical doses there was no detectable portal or systemic exposure of man to ampiroxicam, indicating that conversion to piroxicam was complete during the absorption process. 3. The pharmacokinetics of piroxicam from ampiroxicam were essentially the same as those after piroxicam itself except that Cmax was slightly lower and tmax was slightly longer after administration of ampiroxicam.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP99464649	Ampiroxicam		99464-64-9	Price

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