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Disposition of Ceftizoxime in Staphylococcal Mastitis in Indian Crossbred Cows

Disposition of Ceftizoxime in Staphylococcal Mastitis in Indian Crossbred Cows

Rinku Buragohain, Tapas Kumar Sar, Indranil Samanta, Ujjwal Biswas, Tapan Kumar Mandal

Vet J. 2019 Mar;245:12-14.

PMID: 30819420

Abstract:

Disposition of ceftizoxime was studied in Indian crossbred cows following a single IV dosing in field conditions. Six healthy lactating and six mastitic crossbred cows were assigned to two groups (Group 1 and Group 2). A single IV administration of ceftizoxime at the dose rate of 20mg/kg was administered to cows in both groups. Peak concentrations were recorded at 5min, decreasing sharply until 1h with plasma concentrations of 46.38±0.30μg/mL; concentrations were below detection limits at 24h. Ceftizoxime achieved peak concentrations at 96h and persisted up to 120h at a concentration of 36.71±0.96μg/mL in the milk of mastitic Indian crossbred cows. Staphylococcal colony count in acute mastitis was 52.33±4.98×105 colony forming units/mL milk and no growth was detected at 96h post-dosing, indicating that ceftizoxime following single IV administration at 20mg/kg may be effective to treat acute staphylococcal mastitis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68401810	Ceftizoxime		68401-81-0	Price

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