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Diterpenes and Sesquiterpenes From the Marine Algicolous Fungus Trichoderma Harzianum X-5

Diterpenes and Sesquiterpenes From the Marine Algicolous Fungus Trichoderma Harzianum X-5

Yin-Ping Song, Sheng-Tao Fang, Feng-Ping Miao, Xiu-Li Yin, Nai-Yun Ji

J Nat Prod. 2018 Nov 26;81(11):2553-2559.

PMID: 30351930

Abstract:

Six new terpenes, including one harziane diterpene, 3 R-hydroxy-9 R,10 R-dihydroharzianone (1), one proharziane diterpene, 11 R-methoxy-5,9,13-proharzitrien-3-ol (2), three cyclonerane sesquiterpenes, 11-methoxy-9-cycloneren-3,7-diol (3), 10-cycloneren-3,5,7-triol (4), and methyl 3,7-dihydroxy-15-cycloneranate (5), and one acorane sesquiterpene, 8-acoren-3,11-diol (6), were isolated from the culture of Trichoderma harzianum X-5, an endophytic fungus obtained from the marine brown alga Laminaria japonica. Their structures and relative configurations were established by analysis of 1D/2D NMR, HREIMS, and IR data, and the absolute configurations were assigned on the basis of ECD curves or biogenetic considerations. These terpenes possess four different carbon skeletons, and compound 2, with a rarely occurring bicyclic framework, represents a possible precursor of tetracyclic harzianes. Compounds 1-6 exhibited growth inhibition of some marine phytoplankton species.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP307531904	1,3,5,7,9,11-Octaisobutyltetracyclo[7.3.3.15,11]octasiloxane-endo-3,7-diol		307531-90-4	Price

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